Seizures are one of the most common symptoms seen in pediatric patients receiving hospice or palliative care. Managing seizures is often complex and can be overwhelming for healthcare providers. While collaboration with a pediatric neurologist is ideal for treating these patients, it isn’t always possible. Therefore, hospice and palliative care practitioners must develop some familiarity with the various treatment options. Through case examples, this session will review possible causes of seizures, discuss non-pharmacological and pharmacological treatment options based on seizure type, and evaluate potential therapy adjustments that may be necessary as patients approach end-of-life.